ProArtLeg® Maxy

Published: 03.01.2018

Support the joints of dogs from adult age or large breed dogs predisposed to cartilage wear

proartleg maxy

It is called glucosamine sulphate and is the result of Italian research, the substance that has demonstrated - for the first time in the world - to stop the progression of osteoarthritis: a degenerative joint disease. Glucosamine allows to stop the 'wear' process of the joints in  the elderly dogs and in the dogs who practice sports.

Normally in the body, glucosamine is present in the joints, synovial fluid, tendons, ligaments and muscles and is synthesized by glucose but in arthritis a metabolic defect occurs in its biosynthesis.

In this situation, the exogenous intake of glucosamine sulphate substitutes the deficiency of that, normally produced by the body.

The administration of glucosamine and chondroitin sulfate to the puppies and to large breed or older dogs,  determines after absorbing action, reinforcement and chondroprotection of bone and cartilaginous structures.

Glucosamine in food supplements is obtained by hydrolysis of chitin derived from the shells of certain crustaceans (marine exoskeletons). Glucosamine is the basic component, that with hyaluronic acid intervenes in the constuction of new cartilage. Chondroitin sulfate belongs to a family of heteropolysaccharides called glycosaminoglycans or GAGs.

In the form of proteoglycans they form the basic substance of the extracellular matrix of connective tissue. Chondroitin sulfate is formed by repetitive linear units consisting of N-acetylgalactosamine and D-glucuronic acid. Chondroitin sulfate is found in the cartilage.

The activity of chondroitin sulfate, especially in combination with glucosamine, can promote and maintain the structure of cartilage (chondroprotection).

In particular:

  • stimulates the synthesis of collagen, which is the main protein found in cartilage;
  • it helps to reduce the activity of enzymes that can accidentally destroy what remains of healthy tissue in a worn out joint;
  • it draws water into the cartilage tissue. Articular cartilage is not supplied by blood but by the synovial fluid, that is essential to nourish and lubricate the joints. The effect of the cartilage pillow is due in fact to the moisture content.

Glucosamine and Chondroitin sulphate supplementation in animals that are predisposed to cartilage wear (but also in humans) is recognized as adequate therapy as in prevention and as in the presence of symptoms such as limping or stiffening of the joints.

The pain caused by the loss of cartilage in the joints can be treated with natural substances, that have long been subject to in-depth studies avoiding long-term use of anti-inflammatory drugs (NSAIDs).

ProTriXan ® - DDFARMA blend that brings together in a balanced and synergistic form, naturally derived components, extensively studied and validated by international scientific literature.
  • Garcinia mangostana L. e.s. phytocomplex standardized in polyphenols extract from the whole plant
  • Garcinia mangostana L . standardized in xanthones α and γ extract from the fruit pericarp
  • Curcuma longa L. titrated in curcumin


Effect of Garcinia Mangostana on cellular oxidation and inflammatory process

Garcinia Mangostana is a typical fruit of various areas of SouthEastern Asia. In the late 90s scientists isolated Xantons from the fruit of Mangosteen. The class of xanthones, polyphenols derived from Benzo-y-pyrone, possesses many pharmacological properties. The most interesting are the high antioxidant and anti-inflammatory power of alpha and gamma mangosteen.
Based on the antioxidant evidence of the fruit, some researchers carried out studies in which the activity of the gamma mangosteen was examined, one of the xanthones present in the fruit, on the cascade of arachidonic acid. The ability of the Gamma Mangosteen to inhibit COX1 and COX2 in dependent concentration mode was highlighted, with a mechanism of action based on the selective inhibition of COXs in a competitive manner.
Garcinia mangostana acts as a joint protector with control of inflammation and joint pain.

Devil's Claw (Arpagophytum procumbens DC) is also a plant to which are attributed proven pharmacological activities, which are in such as in Garcinia mangostana, in improving joint function and control of inflammation and pain associated with it. Its mechanism of action is similar to that of Garcinia Mangostana because it has the ability to intervene in the cascade of arachidonic acid. Devil's Claw contains phytosterols, iridoid glycosides, flavonoids. For its analgesic and anti-inflammatory activity is called natural cortisone.

CURCUMA LONGA L. tit. in curcumin

Turmeric is a natural anti-inflammatory. Administered as a nutritional supplement, turmeric demonstrates pharmacological activity used in cartilage degeneration and rheumatoid arthritis.

Many studies have shown that turmeric may be comparable to conventional and potent anti-inflammatory drugs such as hydrocortisone and phenylbutazone. But unlike these, does not have toxic side effects.

PREVENTION AND TREATMENT OF ARTHRITIS Studies on turmeric have shown that this powerful anti-inflammatory drug can reduce the symptoms associated with rheumatoid arthritis: turmeric is a powerful antioxidant, antioxidants neutralize free radicals that cause painful inflammation and damage to joints affected by arthritis. This is quite significant for older animals who may experience pain associated with arthritis and aging.

"Curcuma-Turmeric is one of the most powerful natural anti-inflammatory drugs available" Dr Randy J. Horwitz - Arizona Center Medical Director 2006


It is a mixer of protein substances: hydrolysed collagen of type II, hyaluronic acid, chondroitin sulfate, essential amino acids.
Collagen, the main protein of our tissues, is essential for structuring the joints, tendons and ligaments. Hyaluronic acid is fluidizing / moisturizing, essential for lubricating the joints.

Type II ° collagen is the most common type of collagen found in articular cartilage and represents 80-90% of total collagen content.

Biocell collagen contains hydrolysed collagen, obtained through a patented technology that allows to extract a high percentage of collagen II, hyaluronic acid and chondroitin sulfate, essential components of the body structure.
This hydrolysed collagen is made up of a molecular structure that allows a quick assimilation and favors more pronounced tissue regenerative processes.



Selenium prevents osteoarticular aging; Vitamins E and C are antioxidants. Vitamin C promotes the formation of native collagen.


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activity of mangostins from Garcinia mangostana” Food
and Chemical Toxicolgy; 46: 688-693, 2008
Keigo Nakatani, Masanori Atsumi, Tsutomu Arakawa, Kenji
Oosawa, Susumu Shimura, Norimichi Nakahata and Yasushi
Ohizumi; “Inibitions of Histamine Release and Prostaglandin E2
Syntesis by Mangosteen, a Thai Medicinal Plant” Biological &
Pharmaceutical Bullettin; 25(9): 1137-1141, 2002)
José Pedraza-Chaverri, Noemí Cárdenas-Rodríguez, Marisol
Orozco-Ibarra, Jazmin M. Pérez-Rojas;“Medicinal properties of
mangosteen (Garcinia mangostana)” Food and Chemical Toxicology,
in press; doi:10.1016/j.fct.2008.07.024, 2008
Yoshikawa M., Harada E., Miki A., Tsukamoto K., Si Qian L.,
Yamahara J., Murakami N. 1994. Antioxidant constituents from the
fruit hulls of mangosteen (Garcinia mangostana L.) originatin in
Vietnam. Yakugaku Zasshi 114, 129-133

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